Local delivery of vascular endothelial growth factor via plga depots for treatment of vascular disease

摘要

Vascular endothelial growth factor (VEGF), a potent mitogen specific for endothelial cells, has been shown to induce angiogenesis in in vitro and in vivo models and is being investigated as a possible therapeutic agent for patients with coronary or peripheral artery disease. Systemic administration of VEGF is not optimal because many diseases -- including solid tumors, ocular diseases, and arthritis -- are characterized by the pathological growth of new capillaries. In addition, systemic VEGF administration causes transient hypotension. Hence, we are developing local delivery systems for VEGF that allow the sustained release of drug from polymer matrices placed at or near the diseased site. One system we are investigating is poly-lactide-co-glycolide (PLGA), a degradable polyester widely used in medical applications.