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Competitive ligand binding assay for detecting neutralizing antibodies
Competitive ligand binding assay for detecting neutralizing antibodies
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机译:用于检测中和抗体的竞争性配体结合测定
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摘要
A immunogenicity assay for detecting the presence of neutralizing antibodies to a biotherapeutic protein wherein the biotherapeutic protein has been administered to a patient in need, comprising the steps of (a) obtaining a sample from the patient; (b) incubating the sample in the presence of a capture reagent; and (c) adding a detecting reagent, wherein a decreased signal relative to a control sample indicates the presence of a neutralizing antibody to the biotherapeutic agent.
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