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Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level
Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level
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机译:他莫昔芬衍生物,用于治疗肿瘤疾病,尤其是HER2蛋白水平高的
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摘要
The invention relates to new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivatives of tamoxifen, where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixtures (MitoTAX). Alkyl triphenylphosphonium derivatives of tamoxifen have the general formula (I):I,where n=8…12 and Z is selected from the group of organic or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the general formula IA:IAwhere n=6…10 and Z has the above mentioned meaning.These compounds are applicable for the treatment of neoplastic diseases, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases, according to the invention, contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I) and/or IA or their corresponding tertiary amine salts.
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