HER2 TAMOXIFEN DERIVATIVES FOR TREATMENT OF NEOPLASTIC DISEASES ESPECIALLY WITH HIGH HER2 PROTEIN LEVEL

摘要

The subject of the present invention is the novel E / Z isomer of an aliphatic triphenylphosphonium derivative of tamoxifen targeting the mitochondria, wherein the aliphatic chain is alkyl or alkenyl, and the corresponding tertiary amine salt and / Mito TAX). The alkyltriphenylphosphonium derivatives of tamoxifen have the general formula I wherein n = 8 to 12 and Z is selected from the group of organic or inorganic salts. The alkenyltriphenylphosphonium derivatives of tamoxifen have the general formula IA in which n = 6 to 10 and Z has the abovementioned meaning. These compounds are applicable to the treatment of neoplastic diseases, especially those with high HER2 protein concentrations. The medicament for the treatment of neoplastic diseases according to the present invention contains at least one E / Z isomer of an aliphatic triphenylphosphonium derivative of tamoxifen of the general formula I and / or IA, or a corresponding tertiary amine salt thereof.