N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS

摘要

The present disclosure provides compounds having FormulaI-A:and the pharmaceutically acceptable salts and solvates thereof, wherein A, Xsup1/sup, Xsup2/sup, Xsup3/supRsup1a/sup, Rsup1b/sup, E, and---are as defined as set forth in the specification. The present disclosure also provides compounds of FormulaI-Afor use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.