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Alpha-2 integrin binding agents and their use to inhibit the proliferation of cancer cells
Alpha-2 integrin binding agents and their use to inhibit the proliferation of cancer cells
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机译:Alpha-2整合素结合剂及其在抑制癌细胞增殖中的用途
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摘要
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.
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