Set of probes to analyze a DNA sample and method to use the same

摘要

This disclosure provides, inter alia, a ligatable complex of formula X-A-B-Z, wherein in the complex sequences X, A, B and Z are ligatably adjacent to one another and held in position by a splint oligonucleotide, and wherein sequence A is a target fragment of a genome, sequence B identifies the locus from which the adjacent sequence A is derived. The ligatable complex can be used to identify a chromosome aneuploidy in cell free DNA, for example.