CRYSTALLINE FORMS OF 1-(3-TERT-BUTYL-1-P-TOLYL-1H-PYRAZOL-5-YL)-3-(5-FLUORO-2-(1-(2-HYDROXYETHYL)-1H-INDAZOL-5-YLOXY)BENZYL) UREA HYDROCHLORIDE

摘要

Provided herein is a hydrogen chloride salt of 1-(3-/t?r/-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydoxyethyl)-1H-indazol-5-yloxy)benzyl)urea, crystalline forms of 1-(3-1/2 ~ butyl-1~ -tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride, processesfor the preparation of said crystalline forms, pharmaceuticalcompositions containing a crystalline form of 1-(3-ri/-r-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride Form B, processes for thepreparation of said compositions, pharmaceuticalcompositions prepared by said methods, and the use of said compositions in thetreatment of various diseases and disorders.