A Facile, Efficient and Green Protocol for the Synthesis of 1-(2-hydroxyethyl)-3-alkyl/ary /aralkyl/hydroxyethyl-5-oxo octahydroquinazolines and 3,3-(alkanediyl)bis(1-(2-hydroxyethyl)-5 oxo-octahydroquinazolines)

摘要

A facile microwave assisted one-pot synthesis of novel 1-(2-hydroxyethyl)-3-alkyl/aryl/aralkyl/hydroxyethyl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolines 3a-h and 3,3’-(alkanediyl) bis (1-(2-hydroxyethyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolines) 4a-d has been devised by the cyclocondensation of cyclic enaminones 2a-b with primary amines/diamines and formaldehyde. The structures of the products have been established by spectral and analytical data. The present paper describes a one-pot, efficient, clean, simple, fast and environment friendly strategy for the synthesis of hitherto unknown octahydroquinazolines and bis-octahydroquinazolines from easily accessible starting materials in good yields with promising biological properties. The methodology reported herein is an example of multi-component reactions (MCRs).