METHOD FOR EVALUATING EFFICACY OF DRUG FOR REVERSAL OF MULTI-DRUG RESISTANCE OF TUMORS

摘要

Disclosed in the present invention is a method for evaluating the efficacy of a drug for reversal of multi-drug resistance of tumors. In the present invention, mass spectrums of urine samples and/or serum samples of a healthy group, a negative control group, a positive control group, and a group treated with a drug to be evaluated are detected, the mass spectrum of the sample of the group treated with a drug to be evaluated is compared with the mass spectrum of the sample of the negative control group, so as to calculate the difference between the peak areas of characteristic fragment particle peaks of each metabolic marker in the sample of the group treated with a drug to be evaluated and in the sample of the negative control group, and the multi-drug resistance of the drug to be evaluated is evaluated by the difference. The larger the difference, that is, the larger the value of the reversal adjustment value, the better the effect of reversing the multi-drug resistance of tumors. Experiments verify that the method of the present application can accurately evaluate the efficacy of a drug for reversal of multi-drug resistance of tumors, moreover, the method of the present application can also be applied to the early diagnosis of drug resistance produced by liver cancer cells.