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Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti PD-Ll antibody and an oncolytic virus
Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti PD-Ll antibody and an oncolytic virus
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机译:用抗PD-L1抗体和溶瘤病毒治疗具有肝转移的三阴性乳腺癌或大肠癌
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摘要
Provided herein are methods of treating a subject with triple negative breast cancer or colorectal cancer. In exemplary embodiments, the method comprises administering to the subject a combination of an oncolytic virus, such as talimogene laherparepvec, and an anti-PD-Ll antibody, such as atezolizumab. In exemplary aspects, the oncolytic virus is administered to the subject at an initial dose followed by a second dose, wherein the initial dose is lower than the second dose. In exemplary aspects, the oncolytic virus is intrahepatically administered to the subject.
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