TREATMENT OF TRIPLE NEGATIVE BREAST CANCER OR COLORECTAL CANCER WITH LIVER METASTASES WITH AN ANTI PD-L1 ANTIBODY AND AN ONCOLYTIC VIRUS

摘要

Provided herein are methods of treating a subject with triple negative breastcancer or colorectal cancer. In exemplaryembodiments, the method comprises administering to the subject a combinationof an oncolytic virus, such as talimogene laherparepvec,and an anti-PD-Ll antibody, such as atezolizumab. In exemplary aspects, theoncolytic virus is administered to the subject at an initialdose followed by a second dose, wherein the initial dose is lower than thesecond dose. In exemplary aspects, the oncolytic virus isintrahepatically administered to the subject.