USE OF EXTRACELLULAR VESICLES IN COMBINATION WITH TISSUE PLASMINOGEN ACTIVATOR AND/OR THROMBECTOMY TO TREAT STROKE

摘要

Some embodiments comprise a method and kit for the treatment and prevention of stroke by administering a therapeutically effective combination of mammalian exosomes and/or microvesicles, collectively referred to as extracellular vesicles, and Tissue Plasminogen Activator (tPA), and/or a thrombectomy procedure, to a subject in need thereof. Some embodiments comprise a method and kit for the treatment and prevention of cerebrovascular injury caused by a stroke by administering a therapeutically effective combination of mammalian exosomes, Tissue Plasminogen Activator (tPA), and/or a thrombectomy procedure, to a subject in need thereof. Some embodiments also comprise the administration a therapeutically effective amount of a combination comprising mammalian exosomes and Tissue Plasminogen Activator (tPA) to a subject in need thereof; the mammalian exosomes containing one or more microRNAs selected from miR-19a, miR-21, and miR-146a.