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Activation inducible tissue effector cells suitable for cell therapy and extracellular vesicles derived from it

机译:激活诱导型组织效应细胞,适用于细胞疗法和衍生自IT的细胞外囊泡

摘要

The present invention converts cells into tissue effector cells to produce activated inductive tissue effector cells suitable for use in cell therapy Provides a method of inducing activation of a cell that is not powerful or not sufficiently strong.The present invention further provides an activation inducible tissue effector cell produced thereby and an extracellular vesicle (e.g., exosome) derived from the effector cell (e.g., Astex).The present invention further provides a method of improving the effectiveness of cell therapy by converting cells that are not potent or not sufficiently strong to activated inductive tissue effector cells that have increased potency for cell therapy.The present invention is further a method for treating a disease or state that is applicable to cell therapy in an object that requires it, including administering an effective amount of an active inducible tissue effector cell or an extracellular vesicle derived from the effector cell Provide a method.Diagram
机译:本发明将细胞转化为组织效应细胞以产生适合于细胞疗法的活性感应组织效应细胞提供了一种诱导不强大或不充分强大的细胞活化的方法。本发明还提供了一种活化诱导型组织效应器由此产生的细胞和衍生自效应细胞(例如,astex)的细胞外囊泡(例如,外来体)。本发明进一步提供了通过转化不充气的细胞来改善细胞疗法的有效性的方法,或者不充分强大地激活细胞具有增加的细胞疗法效力增加的感应组织效应细胞。本发明还是治疗适用于需要它的物体中的细胞疗法的疾病或状态的方法,包括给予有效量的活性诱导型组织效应细胞或衍生自效应细胞的细胞外囊泡提供方法.diag内存

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