Tissue-type plasminogen activator is a modulator of the synaptic vesicle cycle

摘要

Tissue-type plasminogen activator(t PA)is a serine proteinase that catalyzes the conversion of plasminogen into plasmin.For a long time after its discovery it was thought that t PA’s main source was the endothelial cell and that therefore its chief role was to generate plasmin in the vascular system.However,this concept was challenged four decades later when a group of investigators detected t PA m RNA in well-defined areas of