Granular composition, method for producing granular composition, and method for improving elution property of granular composition

摘要

Provided is a method for producing a granular composition which is improved in the elution of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyl- oxy}-N-(methylsulfonyl)acetamide. The method for producing the granular composition includes a compression molding step of compression-molding a mixture prepared by mixing 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyl- oxy}-N-(methylsulfonyl)acetamide with at least one excipient selected from the group consisting of a sugar alcohol, a starch and a sugar to produce a compression-molded product.