ANTI-H7N9 FULLY HUMAN MONOCLONAL ANTIBODY 4E18, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

摘要

An anti-H7N9 fully human monoclonal antibody 4E18, a preparation method therefor, and an application thereof. Fully human monoclonal antibody 4E18 without containing any murine components is quickly screened by using memory B cells and a PCR method. The antibody can target hemagglutinin (HA) that binds to H7N9 viruses, and has neutralizing activity against H7N9 virus infection; no human anti-mouse antibody reaction would occur, and better biocompatibility is provided.