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HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS

机译:杂环衍生物作为Nav1.7和Nav1.8阻滞剂

摘要

The present invention relates to heterocyclic derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
机译:本发明涉及杂环衍生物,其具有作为Nav1.7和Nav1.8通道的电压门控钠通道的阻断活性,并且可用于治疗或预防涉及电压门控钠通道的病症和疾病。本发明还涉及包含这些化合物的药物组合物,以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的此类疾病中的用途。

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