COMPOUNDS HAVING ANTI-CDK4/6 AND ANTI-CDK9 ENZYMATIC ACTIVITIES FOR INHIBITING CANCER PROLIFERATION AND RELATED SCREENING METHOD FOR THEIR DETECTION

摘要

The present invention describes the surprising finding that only certain CDK inhibitors, those possessing a certain balance between the enzymatic activities against CDK4/6 and CDK9 protein complexes (for example an optimal ratio between 1:2 and 1:5) showed the highest efficacy in inhibiting cancer proliferation.