PURMORPHAMINE AS A SMALL COMPOUND POSITIVE ALLOSTERIC MODULATOR OF SECRETIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION

摘要

The compositions and the use thereof for treating hypertension are provided, wherein the compositions comprise KSD179019, a derivative thereof or a pharmaceutically accceptable salt thereof. Also provided are methods to design and manufacture KSD179019 analogs and derivatives with enhanced and prolonged anti-hypertensive therapeutic efficacy.