Nd1-L A method of screening autophagy regulating material using Nd1-L

摘要

The present invention relates to a screening method of an autophagy regulating material. The screening method comprises: a step (a) of treating a nerve cell with a test material; and a step (b) of placing Nd-1 protein present in the nucleus and cytoplasm into stress aggregates compared to a control group not treated with the test material or selecting a material increasing the binding of Nd1-L protein and GABARAP or the binding of Nd1-L protein and GABARAPL1. The screening method of an autophagy regulating material of the present invention finds a link between the stress aggregate of Nd1-L protein and the activation of autophagy and can be useful for developing candidate materials for the treatment of brain diseases related to the stress aggregate regulation mechanism in the field of degenerative brain disease.