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Accelerating High-Throughput Screening for Structural Materials with Production Management Methods

机译:通过生产管理方法加快结构材料的高通量筛选

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摘要

High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throughput testing to the development of metallic materials. In addition to new generating and testing methods, these types of high-throughput systems need a logistical control and handling method to reduce throughput time to get test results faster. Instead of the direct material flow found in classical high-throughput screenings, these systems have a very complex structure of material flow. The result is a highly dynamic system that includes short-term changes such as rerun stations, partial tests, and temporarily paced sequences between working systems. This paper presents a framework that divides the actions for system acceleration into three main sections. First, methods for special applications in high-throughput systems are designed or adapted to speed up the generation, treatment, and testing processes. Second, methods are needed to process trial plans and to control test orders, which can efficiently reduce waiting times. The third part of the framework describes procedures for handling samples. This reduces non-productive times and reduces order processing in individual lots.
机译:高通量筛选被进化研究广泛用于新药开发和具有所需特性的新药开发。当前的研究项目将高通量测试的原理转移到金属材料的开发中。除了新的生成和测试方法外,这些类型的高通量系统还需要一种后勤控制和处理方法,以减少吞吐时间,从而更快地获得测试结果。这些系统具有非常复杂的物料流结构,而不是经典的高通量筛选中发现的直接物料流。结果是一个高度动态的系统,其中包括短期更改,例如重新运行站,部分测试以及工作系统之间的临时定序序列。本文提出了一个框架,该框架将系统加速的动作分为三个主要部分。首先,设计或修改高通量系统中特殊应用的方法,以加快生成,处理和测试过程。其次,需要一些方法来处理试验计划和控制测试订单,从而可以有效地减少等待时间。框架的第三部分描述了处理样本的过程。这样可以减少非生产时间,并减少单个批次中的订单处理。

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