SrbA Recombinant strains expressing fusion protein which fragment of SrbA protein and golgi resident protein fused and its application

摘要

The present invention relates to a recombinant vector comprising a gene encoding a SrbA protein fragment and a gene encoding an early golgi resident protein, and a ΔsrbA recombinant Aspergillus nidulans strain transformed with the vector. will be. Therefore, the strain transformed with the recombinant vector of the present invention can overexpress a higher level of ergosterol or genes related to its synthesis even under normal oxygen conditions compared to the wild-type strain, and thus, the strain for ergosterol production or the ergosterol production method using the same Can provide. In addition, when the DUF2014 domain of the sterol regulatory element binding protein of Ascomycetes or its homolog protein is inhibited, the activation of the protein, which is essential for the growth of ascomycetes, is inhibited. Therefore, the present invention can provide a method for inhibiting hypoxic growth of associa fungi.