Polymeric prodrugs and their subcutaneous and/or intramuscular administration

摘要

The present invention relates to novel prodrugs of active molecules. These prodrugs specifically allow subcutaneous or intramuscular administration of the active molecule, and subcutaneous or intramuscular administration of the active molecule is particularly problematic or impossible due to toxicity at the injection site. The prodrugs of the present invention comprise an active ingredient covalently linked to a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The present invention specifically relates to a polymer chain formed at least in part from an acrylamide monomer or a derivative thereof, wherein the polymer comprises a proximal portion and a terminal portion; A first pharmaceutically active molecule covalently coupled to the proximal portion of the polymer; Optionally, it comprises a second pharmaceutically active molecule covalently coupled to the end of the polymer.