Pharmacokinetic behavior of marbofloxacin after intravenous, subcutaneous and intramuscular administrations in llamas (Lama glama).

摘要

The purpose of this study was to determine the pharmacokinetic profile of marbofloxacin in llamas following single IV, IM and SC administration of 5 mg/kg bw. To assess whether these routes could be an option for the administration of marbofloxacin in this specie and estimate efficacy predictors (PK/PD) from bibliographic MIC₉₀ values. The principal pharmacokinetic parameters were V_ss=0.72+or-0.22 L/kg, Cl=0.09+or-0.03 L/kg h (for IV administration), C_max=7.43+or-1.28 micro g/mL and 6.94+or-2.19 micro g/mL for IM and SC administration, respectively; t_{1/2 lambda} =9.16+or-1.08 h, 8.47+or-0.31 h and 6.26+or-0.87 h and MRT=7.30+or-1.07 h, 8.21+or-1.57 h and 8.27+or-0.96 h for IV, IM and SC administrations, respectively. The values obtained for the pharmacokinetic parameters were not significantly different among routes of administration except C_max, V_z and t_{1/2 lambda} . The values obtained from the PK/PD indices were C_max/MIC₉₀ (12.4-32.3) and AUC_0-24/MIC₉₀ (105.7-178.52 h); taking into account these values, it was concluded that a IM or SC dose of 5 mg/(kg day) of marbofloxacin would be adequate in treating infections caused by susceptible bacteria with MIC <0.44 micro g/mL.