The present invention relates to a method for producing sonidegib (LDE225), which produces cis -2R, 2'S-bis) ether by an intermolecular condensation reaction of L-lactate, an industrial raw material that can be easily obtained. , Through sulfonylation reaction and ring-closure reaction with N- (6-aminopyridin-3-yl) -2-methyl-4 '-(trifluoromethoxy)-[1,1'-biphenyl] -3- Sonny Degib (I) will be manufactured. This manufacturing method is easy to obtain raw materials, simple process, economical, eco-friendly and industrial production.
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