-CGRP ANTI-CGRP COMPOSITIONS AND USE THEREOF

摘要

The present invention relates to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of the invention relates to antibodies described herein, and binding fragments thereof, which include the sequences of the V _H , V _L and CDR polypeptides described herein, and the polynucleotides encoding them. The present invention also contemplates conjugates of anti-CGRP antibodies conjugated to one or more functional or detectable moieties and binding fragments thereof. The present invention also contemplates a method for preparing the anti-CGRP antibody and binding fragments thereof. Embodiments of the invention also relate to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, evaluation and treatment of diseases and disorders associated with CGRP.