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TRK MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

机译：TRK大环化合物作为TRK激酶抑制剂

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Compounds of formula I :I And pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R ² , R ^2a , R ³ , R ^3a , and Z are as defined herein, an inhibitor of silver Trk kinase And is useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

机译：式 I ： I 的化合物及其药学上可接受的盐，其中环A，环B，W，m，D，R ^{2 ，R ^{2a ，R ^{3 ，R ^{3a 和Z如本文所定义，是银Trk激酶的抑制剂，可用于治疗疼痛，癌症，炎症，神经退行性疾病和某些传染病。}}}} 展开▼

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公开/公告号KR102132405B1

专利类型

公开/公告日2020-07-09

原文格式PDF

申请/专利权人 어레이 바이오파마 인크.;
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申请/专利号KR20197024602

发明设计人 앤드류스 스티븐 웨이드;콘드로스키 케빈 로날드;하스 줄리아;장 위퉁;콜라코브스키 가브리엘 알.;서 정법;양 홍-원;자오 퀴안;
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申请日2011-05-13

分类号C07D487/22;A61K31/519;A61P25;A61P35;C07D471/22;C07D498/22;

国家 KR

入库时间 2022-08-21 11:04:18

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1. 作为TRK激酶抑制剂的大环化合物 [P] . 中国专利： CN110003209B . 2022.01.25

2. 作为TRK激酶抑制剂的大环化合物 [P] . 中国专利： CN111971287A . 2020-11-20

3. TRK MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS [P] . 韩国专利： KR20200085364A . 2020-07-14

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4. TRK MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS [P] . 韩国专利： KR20190101498A . 2019-08-30

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5. TRK MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS [P] . 韩国专利： KR102015402B1 . 2019-08-28

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1. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors [J] . Drilon Alexander, Nagasubramanian Ramamoorthy, Blake James F., Cancer discovery. . 2017,第9期

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5. Determining the functional role of tropomyosin receptor kinase (Trk) in neuroblastoma [D] . Jaboin, Jerry J. 2004

6. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors [O] . Alexander Drilon, Ramamoorthy Nagasubramanian, James F. Blake, -1

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