Cargo-switching dissociable nanobiomaterial for treatment of atherosclerosis

摘要

The present invention relates to a cargo-substituted degradable nanobiomaterial for the treatment of atherosclerosis, wherein the complex of the cyclodextrin or cyclodextrin derivative, and the statin-based compound of the present invention decomposes cholesterol crystals by substituting cholesterol and statins from cholesterol crystals, Since it is absorbed into macrophages and foam cells to induce apoptosis, it inhibits atherosclerosis and degenerates arteriosclerotic plaques, so it can be usefully used for the prevention or treatment of atherosclerosis.