METHOD FOR SIMULATING TOXIC HEART INVOLVEMENT IN RATS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to experimental medicine and pharmacology and can be used for studying the toxic effect on the cardiac conduction system in pre-clinical study of new cardioprotective agents, studying mechanisms of their action and developing new methods of treatment. A method for modeling toxic cardiac involvement in rats involves toxic cardiac involvement in animals by daily at least 2 weeks of administration of a complex of antituberculous preparations moxifloxacin, bedaquiline, linezolid, protionamide and capreomycin, rat females aged 10–12 months and weighing 330–350 g used for modeling.;EFFECT: invention provides good reproducibility, absence of lethal outcome of experimental animals and short period of development of pathological condition.;5 cl, 3 dwg, 3 tbl