CELLULES IMMUNITAIRES MODIFIÉES CO-EXPRIMANT UN RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE ET UN ANTAGONISTE DE L'IL-6 POUR DIMINUER LA TOXICITÉ, ET UTILISATIONS DE CES DERNIÈRES EN THÉRAPIE CELLULAIRE ADOPTIVE

摘要

A population of immune cells comprising modified immune cells co-expressing a chimeric antigen receptor and an IL-6 signaling antagonist (e.g., an anti-IL6 or anti-IL-6R antibody) and optionally an IL-1 signaling antagonist. Also provided herein are methods of producing such immune cell populations comprising the modified immune cells and methods of using such in cell therapy (e.g., to treat cancer, infectious diseases, or immune diseases).