UTILISATION DE CELLULES T DE RÉCEPTEUR MODIFIÉ D'ANTIGÈNE CHIMÉRIQUE POUR TRAITER LE CANCER

摘要

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.