Biotin variants, streptavidin variants and their use

摘要

PROBLEM TO BE SOLVED: To provide a streptavidin mutant that has reduced affinity for natural biotin, and further to provide a biotin variant that has high affinity for the streptavidin mutant having low affinity for natural biotin.SOLUTION: According to the present invention, there is provided a compound comprising a dimer of a biotin variant, a streptavidin mutant, and use thereof.SELECTED DRAWING: None