A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part, wherein(1) in the neural retina, a neural retinal layer including at least a photoreceptor layer is formed, wherein the photoreceptor layer contains one or more types of cells selected from the group consisting of at least a photoreceptor cell, a photoreceptor progenitor cell, and a retinal progenitor cell, and the cells contained in the photoreceptor layer are continuously present in a tangential direction to the surface of the core part;(2) the covering part contains retinal pigment epithelial cells in contact with each other;(3) the sphere-like cell aggregate is free of a crystalline lens, a vitreous, a cornea, and a blood vessel; and(4) the retinal pigment epithelial cells do not constitute an epithelial structure continued with the neural retinal layer.
展开▼
