POLYPEPTIDES MULTIMÈRES MODULATEURS DES LYMPHOCYTES T ET LEURS MÉTHODES D'UTILISATION

摘要

The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co- immunomodulatory polypeptide. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.