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抗体组合物及其筛查髓系疾病及检测免疫检查点的应用

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摘要

本发明提供了一种抗体组合物及其筛查髓系疾病及检测免疫检查点的应用。所述抗体组合物包括抗CD15抗体、抗CD96抗体、抗CD33抗体、抗CD34抗体、抗CD117抗体、抗CD9抗体、抗CD45抗体、抗CD38抗体、抗HLA‑DR抗体、抗CD13抗体、抗CD19抗体、抗CD4抗体、抗CD36抗体、抗CD7抗体、抗CD371抗体、抗CD11c抗体、抗CD11b抗体、抗CD200抗体、抗CD14抗体、抗CD56抗体、抗CD71抗体、抗CD2抗体、抗CD123抗体和抗CD64抗体。本发明的抗体组合物可应用于筛查髓系疾病及检测免疫检查点。

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公开/公告号CN112630438B

专利类型发明专利
公开/公告日2021-06-22

原文格式PDF
申请/专利权人信纳克(北京)生化标志物检测医学研究有限责任公司;
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申请/专利号CN202110249801.1
发明设计人王卉;陈曼;傅旻婧;
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申请日2021-03-08
分类号G01N33/577(20060101);G01N33/574(20060101);G01N33/569(20060101);G01N33/68(20060101);G01N33/58(20060101);G01N15/14(20060101);
代理机构11127 北京三友知识产权代理有限公司;
代理人韩蕾;姚亮
地址 100176 北京市大兴区北京经济技术开发区同济南路22号院2幢D区
入库时间 2022-08-23 11:59:40

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1. 抗体组合物及其筛查髓系疾病及检测免疫检查点的应用 [P] . 中国专利： CN112630438B . 2021.06.22
2. 抗体组合物及其筛查髓系疾病及检测免疫检查点的应用 [P] . 中国专利： CN112630438A . 2021-04-09
3. isolated human antibody, method of treating a condition caused by increased ngf expression or increased ngf sensitivity in a patient, pharmaceutical composition, method for detecting ngf in a biological sample, nucleic acid molecule, host cell, isolated cell line, ngf-specific binding agent, isolated human antibody or immunologically functional immunoglobulin fragment or antigen binder thereof, polynucleotide, expression vector, medicament for treating a painful disorder or condition associated with increased ngf expression or increased sensitivity to ngf, and, use of a pharmaceutically effective amount of antibody [P] . BRPI0412567A . 2006-09-19

机译：分离的人抗体，治疗患者中ngf表达增加或ngf敏感性增加引起的疾病的方法，药物组合物，生物样品中ngf的检测方法，核酸分子，宿主细胞，分离的细胞系，ngf特异性结合剂，分离的人抗体或其免疫功能性免疫球蛋白片段或其抗原结合剂，多核苷酸，表达载体，用于治疗与ngf表达增加或对ngf敏感性增加相关的疼痛性疾病或病症的药物，以及药物有效量的抗体的用途
4. Methods for extracting or inducing, in a mammal, a parasite-directed immune response, to treat a mammal for parasitic infection therapeutically or prophylactically, for the treatment and / or prophylaxis of an unhealthy mammalian condition, use of a composition, composition, vaccine composition, pharmaceutical composition, antibody for inhibiting, stopping or delaying the onset or progression of an unhealthy mammalian condition, use of an antibody, methods for detecting an immunoreactive molecule directed at a microorganism in a biological sample and to detect, monitor or otherwise evaluate an immune response directed to a microorganism in an individual, modular kit, method for analyzing, designing and / or modifying an agent capable of interacting with an anti-gpi glycan immunointeractive molecule binding site. , and, agent use [P] . BR0312985A . 2005-06-21

机译：组合物，组合物，疫苗组合物的用途，用于在哺乳动物中提取或诱导针对寄生虫的免疫应答，以治疗性或预防性地治疗哺乳动物以治疗寄生虫感染，用于治疗和/或预防不健康的哺乳动物疾病。，药物组合物，用于抑制，阻止或延迟不健康哺乳动物疾病的发作或发展的抗体，抗体的用途，用于检测针对生物样品中微生物的免疫反应性分子并检测，监测或评估免疫的方法在单独的模块化试剂盒中针对微生物的响应进行分析，设计和/或修饰能够与抗gpi聚糖免疫相互作用分子结合位点相互作用的试剂的方法。和代理商使用
5. Hmw protein of the isolated chlamydia species, isolated nucleic acid molecule, recombinant expression vector, transformed host cell, isolated recombinant protein or fragment or analog thereof, immunogenic composition, antigenic composition, processes to produce an immune response in an animal, anti- serum, antibodies, diagnostic reagent, to detect anti-chlamydia antibodies in a test sample, to detect the presence of chlamydia in a test sample, to prevent, treat or ameliorate a chlamydia-related disorder in a host in need of this treatment , and to determine the presence of nucleic acid encoding an hmw protein or a fragment or analog thereof in a sample, diagnostic kits to detect antibodies to chlamydia, and to determine the presence of nucleic acid encoding an hmw protein or fragment or analog thereof in a sample, vaccine composition, and pharmaceutical composition The [P] . BR9813841A . 2000-10-03

机译：分离的衣原体物种的Hmw蛋白，分离的核酸分子，重组表达载体，转化的宿主细胞，分离的重组蛋白或其片段或类似物，免疫原性组合物，抗原性组合物，在动物中产生免疫应答的过程，抗血清，抗体，诊断试剂，用于检测测试样品中的衣原体抗体，检测测试样品中的衣原体，预防，治疗或缓解需要此治疗的宿主中的衣原体相关疾病，并确定样品中是否存在编码hmw蛋白或其片段或类似物的核酸，诊断试剂盒以检测针对衣原体的抗体以及确定样品，疫苗组合物中是否存在编码hmw蛋白或其片段或类似物的核酸和药物成分