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一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用

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摘要

本发明涉及一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用，所述基于抗体的乙酰胆碱酯酶芯片固定方法包括以下步骤：（1）将乙酰胆碱酯酶抗体固定于芯片表面；以及（2）使乙酰胆碱酯酶流入芯片表面从而结合于所述乙酰胆碱酯酶抗体上。

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公开/公告号CN109239153B

专利类型发明专利
公开/公告日2021-06-01

原文格式PDF
申请/专利权人上海交通大学医学院;
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申请/专利号CN201810935936.1
发明设计人王昊;徐见容;陈红专;胡梦薇;赵兰雪;侯丽娜;王宇;李苗苗;黄婉莹;
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申请日2018-08-16
分类号G01N27/327(20060101);
代理机构31261 上海瀚桥专利代理事务所(普通合伙);
代理人郑优丽;熊子君
地址 200025 上海市黄浦区重庆南路280号
入库时间 2022-08-23 11:53:13

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1. 一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用 [P] . 中国专利： CN109239153B . 2021.06.01
2. 一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用 [P] . 中国专利： CN109239153A . 2019-01-18
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4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

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