首页> 中国专利> 式I的雷帕霉素化合物在制备用于治疗实体瘤的药物组合物中的用途

式I的雷帕霉素化合物在制备用于治疗实体瘤的药物组合物中的用途

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摘要
著录项
法律信息
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摘要

雷帕霉素衍生物，任选地与化疗剂联合，在对实体瘤的治疗中有令人感兴趣的效果。

著录项

公开/公告号CN1296043C

专利类型发明授权
公开/公告日2007-01-24

原文格式PDF
申请/专利权人诺瓦提斯公司;
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申请/专利号CN200510055458.8
发明设计人 H·莱恩;T·奥赖利;J·M·伍德;
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申请日2002-02-18
分类号A61K31/436(20060101);A61P35/00(20060101);
代理机构11247 北京市中咨律师事务所;
代理人黄革生;安佩东
地址瑞士巴塞尔
入库时间 2022-08-23 08:59:15

法律信息

法律状态公告日

法律状态信息

法律状态
2014-09-10

专利权全部无效 IPC(主分类):A61K 31/436 授权公告日:20070124 无效宣告决定日:20120509 无效宣告决定号:18448 申请日:20020218

专利权的无效宣告
2013-11-27

专利权人的姓名或者名称、地址的变更 IPC(主分类):A61K 31/436 变更前: 变更后: 申请日:20020218

专利权人的姓名或者名称、地址的变更
2007-01-24

授权

授权
2005-12-07

实质审查的生效

实质审查的生效
2005-10-12

公开

公开

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1. 式I的雷帕霉素化合物在制备用于治疗实体瘤的药物组合物中的用途 [P] . 中国专利： CN1296043C . 2007.01.24
2. 组合物在制备用于在实体瘤的患者进行栓塞治疗中在循环系统中形成栓塞的药物中的用途 [P] . 中国专利： CN106344968B . 2019.09.24
3. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
4. compound, pharmaceutical composition, use of a compound for the preparation of a medicament for the treatment of a condition resulting from an abnormality of nitric oxide production, use of a compound for the preparation of a medicament for the treatment of pain in an individual with need thereof and use of a compound for the preparation of a medicament for the treatment of inhibition of dimerization of inos [P] . BRPI0518096A . 2008-10-28

机译：化合物，药物组合物，该化合物在制备用于治疗由一氧化氮产生异常导致的病症的药物中的用途，该化合物在制备用于治疗有需要的个体中的疼痛的药物中的用途化合物及其在制备药物中的用途，所述药物用于抑制肌苷二聚化
5. compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b) [P] . BRPI0613031A2 . 2012-01-03

机译：化合物，药物组合物;该化合物在制备用于治疗肠易激综合症，治疗疼痛或疼痛综合症，治疗尿失禁，治疗抑郁症，纤维肌痛，焦虑症，恐慌症，广场恐惧症，创伤前应激障碍，烦躁不安症，月经失调的药物中的用途，注意力缺陷障碍，强迫症，社交焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，抽动秽语综合征，血管舒缩放电，可卡因成瘾，性功能障碍，人格阈障碍，纤维肌痛综合征，糖尿病性神经性疼痛，慢性疲劳综合症，害羞药物综合征，雷诺氏综合症，帕金森氏病和癫痫病，结构式（a）的化合物的制备方法和结构式（b）的化合物的制备方法