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一种针对蛔虫三期幼虫特异表达的miRNA—asu-miR-36f的抑制剂及其应用

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摘要

本发明提供一种针对蛔虫三期幼虫特异表达的miRNA—asu‑miR‑36f的抑制剂，该抑制剂可以特异性的抑制猪蛔虫三期幼虫特异表达的asu‑miR‑36f。所述抑制剂的核苷酸序列为：UGACAAGGAUUGCAGCCCGGUGA。本发明的抑制剂通过与asu‑miR‑36f结合，显著降低了asu‑miR‑36f的丰度，并且显著影响了猪蛔虫三期幼虫的发育及降低了感染率。本发明所提供的蛔虫三期幼虫特异表达的miRNA—asu‑miR‑36f抑制剂可应用于影响猪蛔虫和人蛔虫三期幼虫生长发育或与其感染性相关的功能。

著录项

公开/公告号CN104726455B

专利类型发明专利
公开/公告日2018-05-01

原文格式PDF
申请/专利权人中国农业科学院兰州兽医研究所;
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申请/专利号CN201510071461.2
发明设计人徐民俊;冯胜勇;邵长春;朱兴全;
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申请日2015-02-11
分类号
代理机构北京中恒高博知识产权代理有限公司;
代理人吕玉博
地址 730000 甘肃省兰州市城关区盐场堡徐家坪1号
入库时间 2022-08-23 10:10:37

法律信息

法律状态公告日

法律状态信息

法律状态
2018-05-01

授权

授权
2015-07-22

实质审查的生效 IPC(主分类):C12N15/113 申请日:20150211

实质审查的生效
2015-06-24

公开

公开

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