首页> 中国专利> 一种益康补元片的制备方法及其在抑制小鼠淋巴瘤细胞YAC-1细胞增殖药物中的应用

一种益康补元片的制备方法及其在抑制小鼠淋巴瘤细胞YAC-1细胞增殖药物中的应用

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摘要

本发明属于中药技术领域，具体涉及一种益康补元片的制备方法及应用。本发明的益康补元片的制备方法，由黄芪280g、麻罕80g、当归190g、墨旱莲220g、苍术190g、红花150g、赤芍140g、桃仁140g、牛膝150g、川芎120g、枳壳70g、桔梗100g作为原料药制成，采用超临界萃取和微波萃取制备而成，使得芍药苷含量有很大提高。本发明还提供了益康补元片在制备抑制小鼠淋巴瘤细胞YAC-1细胞增殖药物中的应用。

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公开/公告号CN103690646B

专利类型发明专利
公开/公告日2015-08-19

原文格式PDF
申请/专利权人徐茂航;
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申请/专利号CN201310670597.6
发明设计人任立杰;王璇;刘海妮;
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申请日2013-12-11
分类号A61K36/752(20060101);A61K9/20(20060101);A61P35/00(20060101);
代理机构37205 济南舜源专利事务所有限公司;
代理人徐槐
地址 266000 山东省青岛市李沧区郑佛路17号
入库时间 2022-08-23 09:29:13

法律信息

法律状态公告日

法律状态信息

法律状态
2019-10-18

专利权的转移 IPC(主分类):A61K 36/752 登记生效日:20190925 变更前: 变更后: 申请日:20131211

专利申请权、专利权的转移
2015-08-19

授权

授权
2015-08-19

授权

授权
2015-08-05

著录事项变更 IPC(主分类):A61K36/752 变更前: 变更后: 申请日:20131211

著录事项变更
2015-08-05

专利申请权的转移 IPC(主分类):A61K36/752 变更前: 变更后: 登记生效日:20150717 申请日:20131211

专利申请权、专利权的转移
2015-08-05

著录事项变更 IPC(主分类):A61K 36/752 变更前: 变更后: 申请日:20131211

著录事项变更
2015-08-05

专利申请权的转移 IPC(主分类):A61K 36/752 变更前: 变更后: 登记生效日:20150717 申请日:20131211

专利申请权、专利权的转移
2014-04-30

实质审查的生效 IPC(主分类):A61K36/752 申请日:20131211

实质审查的生效
2014-04-30

实质审查的生效 IPC(主分类):A61K 36/752 申请日:20131211

实质审查的生效
2014-04-02

公开

公开
2014-04-02

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1. 一种益康补元片的制备方法及其在抑制小鼠淋巴瘤细胞YAC-1细胞增殖药物中的应用 [P] . 中国专利： CN103690646B . 2015.08.19
2. 一种益康补元片的制备方法及其在抑制小鼠淋巴瘤细胞L5178Y细胞增殖药物中的应用 [P] . 中国专利： CN103655838B . 2015.06.24
3. methods to inhibit b cell tumor cell proliferation, to treat a patient having a tumor, to treat a patient having a deregulated taki signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor THAT IS SUSTAINABLE to treatment with a taki inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or methods to inhibit the proliferation of b cell tumor cell, to treat a patient having a tumor, to treat a patient having a deregulated tak1 signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor that is susceptible to treatment with a tak1 inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or suspected of having a tumor for treatment with a medi inhibitor tak1 [P] . BRPI0714158A2 . 2012-12-25

机译：抑制b细胞肿瘤细胞增殖，治疗患有肿瘤的患者，治疗患有taki信号转导分子失调的患者，抑制实体瘤生长，选择具有治疗可持续性的肿瘤的方法使用taki抑制剂来抑制细胞白血病和t细胞淋巴瘤的增殖，并选择具有抑制b细胞肿瘤细胞增殖的哺乳动物或方法，以治疗患有肿瘤的患者，以治疗患有t细胞淋巴瘤的患者失调的tak1信号转导分子，以抑制实体瘤的生长，选择患有对tak1抑制剂治疗敏感的肿瘤的患者，以抑制细胞白血病和t细胞淋巴瘤的增殖，并选择患有或怀疑患有肿瘤的哺乳动物可使用tak1抑制剂治疗
4. DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or [P] . BR0109827A . 2004-07-06

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5. Immunoconjugate, methods for treating multiple myeloma in an individual, for dispensing immunoconjugate-mediated drug, for inhibiting, delaying and / or preventing tumor development and / or dispensing malignant tumor cells in a patient in need thereof, for treating an individual having a condition and to decrease the amount of cells in direct or indirect contact with immunoconjugates, a method for treating multiple myeloma in an individual, to dispense immunoconjugate-mediated medication, to inhibit, delay and / or prevent tumor cell development in a cell culture, to inhibit, delay and / or prevent the development of a tumor and / or dispense malignant tumor cells in a patient in need thereof, to treat an individual having a condition and to decrease a number of cells in direct or indirect contact. with tumor cells, pharmaceutical composition, and kit. [P] . BRPI0821449A2 . 2015-06-16

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