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Panx1蛋白在制备神经病理性疼痛防治药物中的作用

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摘要

本发明公开了缝隙连接蛋白Panx1在制备神经病理性疼痛防治药物中的作用，属于生物医药技术领域。本发明确定了施万细胞中主要表达Panx1，慢性神经性病理损伤能引起其表达量显著增加；Panx1的抑制剂和模拟肽，能显著抑制坐骨神经慢性神经病理性损伤引起的机械痛和热痛，同时Panx1抑制剂probenecid能显著抑制损伤引起的Panx1的表达。这为将来临床利用Panx1抑制剂治疗慢性神经性病理疼痛患者提供有力的基础研究证据。

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公开/公告号CN113616794A

专利类型发明专利
公开/公告日2021-11-09

原文格式PDF
申请/专利权人南通大学;
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申请/专利号CN202111003210.2
发明设计人韦中亚;陈罡;王茜;凌卓敏;
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申请日2021-08-30
分类号A61K45/00(20060101);A61P25/00(20060101);A61P29/00(20060101);C12Q1/6883(20180101);G01N33/68(20060101);A61K31/56(20060101);A61K31/195(20060101);A61K38/17(20060101);
代理机构32200 南京经纬专利商标代理有限公司;
代理人黄欣
地址 226019 江苏省南通市崇川区啬园路9号
入库时间 2023-06-19 13:13:51

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1. Panx1蛋白在制备神经病理性疼痛防治药物中的作用 [P] . 中国专利： CN113616794A . 2021-11-09
2. 金铃子散在制备防治神经病理性疼痛疾病药物中的应用 [P] . 中国专利： CN108635411A . 2018-10-12
3. In view of their capability to antagonize the actions of neurokinins by blocking the neurokinin receptors, and in particular antagonizing the actions of substance P by blocking the NK1 receptor, the compounds according to the invention are useful as a medicine, in particular in the prophylactic and therapeutic treatment of neurokinin-mediated conditions, such as, for instance CNS disorders, in particular depression, anxiety disorders, stress-related disorders, sleep disorders, cognitive disorders, personality disorders, schizoaffective disorders, eating disorders, neurodegenerative diseases, addiction disorders, mood disorders, sexual dysfunction, pain and other CNS-related conditions; inflammation; allergic disorders; emesis; gastrointestinal disorders, in particular irritable bowel syndrome (IBS); skin disorders; vasospastic diseases; fibrosing and collagen diseases; disorders related to immune enhancement or suppression and rheumatic diseases and body weight control. [P] . EA009217B1 . 2007-12-28

机译：考虑到它们通过阻断神经激肽受体来拮抗神经激肽的作用，特别是通过阻断NK1受体来拮抗P物质的作用的能力，根据本发明的化合物可用作药物，特别是在预防和治疗中。治疗神经激肽介导的疾病，例如中枢神经系统疾病，尤其是抑郁症，焦虑症，与压力有关的疾病，睡眠障碍，认知障碍，人格障碍，精神分裂性障碍，进食障碍，神经退行性疾病，成瘾障碍，情绪疾病，性功能障碍，疼痛和其他中枢神经系统相关疾病;炎;过敏性疾病呕吐胃肠道疾病，特别是肠易激综合症（IBS）;皮肤疾病;血管痉挛性疾病;纤维化和胶原蛋白疾病;与免疫增强或抑制，风湿性疾病和体重控制有关的疾病。
4. compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b) [P] . BRPI0613031A2 . 2012-01-03

机译：化合物，药物组合物;该化合物在制备用于治疗肠易激综合症，治疗疼痛或疼痛综合症，治疗尿失禁，治疗抑郁症，纤维肌痛，焦虑症，恐慌症，广场恐惧症，创伤前应激障碍，烦躁不安症，月经失调的药物中的用途，注意力缺陷障碍，强迫症，社交焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，抽动秽语综合征，血管舒缩放电，可卡因成瘾，性功能障碍，人格阈障碍，纤维肌痛综合征，糖尿病性神经性疼痛，慢性疲劳综合症，害羞药物综合征，雷诺氏综合症，帕金森氏病和癫痫病，结构式（a）的化合物的制备方法和结构式（b）的化合物的制备方法
5. Prodrug compound of a compound originating from pharmaceutical composition processes to antagonize the effect of substance p at its receptor site or to block neurokinin-1 receptors in a mammal to treat or prevent pain or nociception attributable to or associated with migraine a condition selected from the group consisting of of AIDS-related peripheral diabetic neuropathy induced by chemotherapy and neuralgia asthma emesis and arthritis to treat cystic fibrosis and process to prepare [P] . BR9507046A . 1997-09-09

机译：源自药物组合物过程的化合物的前药化合物，其拮抗p物质在其受体位点的作用或阻断哺乳动物中神经激肽-1受体的作用，以治疗或预防可归因于偏头痛或与之相关的疼痛或伤害感受，所述症状选自以下组由化学疗法诱发的与艾滋病相关的周围性糖尿病神经病，神经痛，哮喘，呕吐和关节炎组成，用于治疗囊性纤维化和制备方法