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治疗CASTOR相关疾病的方法

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摘要

本公开涉及通过CoA水平的小分子调节剂治疗辅酶A减少、升高、螯合、毒性或再分布(CASTOR)疾病，例如脂肪酸氧化酶、甲基丙二酸血症，戊二酸血症，丙酸血症和HMG‑CoA裂解酶中的缺陷的方法。本摘要旨在作为在特定技术中用于搜索的扫描工具，而并非旨在限制本发明。

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公开/公告号CN111787939A

专利类型发明专利
公开/公告日2020-10-16

原文格式PDF
申请/专利权人圣朱德儿童研究医院有限公司;COA治疗有限公司;
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申请/专利号CN201880084523.5
发明设计人 S·贾可斯基;C·O·罗克;R·E·李;L·K·夏尔马;尹美京;C·苏布兰马尼安;R·P·唐加拉帕利;A·V·爱德华;R·赞博尼;T·J·雷迪;刘九雨;
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申请日2018-12-26
分类号A61K38/43(20060101);A61P35/00(20060101);
代理机构31266 上海一平知识产权代理有限公司;
代理人马莉华;徐迅
地址美国田纳西州
入库时间 2023-06-19 08:33:20

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机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
4. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, methods of treatment and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, and to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, type 2 diabetes arteriosclerosis, conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412472A . 2006-09-19

机译：化合物，化合物的制备方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，心血管疾病，高胆固醇血症的治疗和/或预防方法与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 ldl，炎性疾病，阿尔茨海默氏病，2型糖尿病动脉硬化，与需要改善hdl功能相关的疾病以及药物成分
5. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, and methods of treating and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, atherosclerosis, type 2 diabetes, and conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412479A . 2006-09-19

机译：化合物，制备化合物的方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，以及治疗和/或预防心血管疾病的方法，高胆固醇血症，与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 IDL，炎性疾病，阿尔茨海默氏病，动脉粥样硬化，2型糖尿病以及与需要改善HDL功能相关的疾病以及药物成分