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用于耗尽CD2+细胞的组合物和方法

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摘要

本发明提供了用作治疗干细胞紊乱、癌症或自身免疫性疾病以及其他血液学疾病和增殖性疾病的剂的抗CD2抗体、其抗原结合片段及其抗体‑药物缀合物。本文描述的组合物和方法可以用于耗尽CD2+细胞诸如CD2+癌细胞和CD2+免疫细胞的群体，并且可以用于使患者准备好进行造血干细胞移植。

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公开/公告号CN111670200A

专利类型发明专利
公开/公告日2020-09-15

原文格式PDF
申请/专利权人美真达治疗公司;
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申请/专利号CN201880088127.X
发明设计人安东尼·博伊坦诺;迈克尔·库克;拉胡尔·帕尔乔杜里;肖恩·麦克唐纳;
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申请日2018-11-29
分类号C07K16/28(20060101);A61K38/00(20060101);
代理机构11262 北京安信方达知识产权代理有限公司;
代理人王玮玮;郑霞
地址美国马萨诸塞州
入库时间 2023-06-19 08:16:01

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3. the pharmaceutical method and composition for the prevention or treatment of a disease or an autoimmune or infectious condition, pharmaceutical method and composition for the prevention or treatment of a disease or a condition of blood, pharmaceutical method and composition to modulate the formation of blood cells, Pharmaceutical method and composition to intensify peripheral mobilisation of stem cell, method and pharmaceutical composition for the prevention or treatment of a disease or metabolic condition,Pharmaceutical method and composition for the prevention or treatment of conditions associated with myeloablive chemotherapy doses supported by autologous bone marrow transplantation or peripheral blood stem cells (asct) or allogeneic bone marrow transplantation (bmt),Pharmaceutical method and composition to increase the effect of a stimulating factor in blood cells, method and pharmaceutical composition to intensify the colonization of donor blood stem cells in a myeloablated recept [P] . BRPI0507822A . 2007-07-10

机译：用于预防或治疗疾病或自身免疫或感染性疾病的药物方法和组合物，用于预防或治疗疾病或血液疾病的药物方法和组合物，调节血细胞形成的药物方法和组合物，增强干细胞外周动员的药物方法和组合物，用于预防或治疗疾病或代谢病的方法和药物组合物，用于预防或治疗与自体骨髓移植支持的骨髓活性化疗剂量有关的病症的药物方法和组合物或外周血干细胞（asct）或同种异体骨髓移植（bmt），增加刺激因子在血细胞中的作用的药物方法和组合物，增强骨髓脱钙受体中供体血干细胞定植的方法和药物组合物
4. composition to induce cell membrane injury; composition for increasing cell membrane injury in a lymphoid cell; composition to permeabilize a cell; composition to induce cell membrane injury in b cells; composition for increasing cell membrane injury induced by a cell membrane injury antibody; method of treating a mammal suffering from a distinct condition due to hyperproliferation of cells; method for killing a cancer cell; method for inducing cell membrane injury in a lymphoid cell in a human patient; method for inducing cell membrane injury; method for permeabilizing a cell; method of purging the bone marrow of malignant b cells from a patient with this need; kit for determining the dose limit for a multipurpose agent that induces injury to the cell membrane in a mammal; kit for determining the dose limit for a cell membrane injury antibody in a mammal; use of a polyvalent cell membrane injury agent; and use of a cell membrane injury antibody [P] . BRPI0517057A . 2008-09-30

机译：诱导细胞膜损伤的组合物;用于增加淋巴样细胞的细胞膜损伤的组合物;透化细胞的成分;诱导b细胞细胞膜损伤的组合物;用于增加由细胞膜损伤抗体诱导的细胞膜损伤的组合物;治疗由于细胞过度增殖而遭受不同状况的哺乳动物的方法;杀死癌细胞的方法;诱导人类患者淋巴细胞细胞膜损伤的方法;诱导细胞膜损伤的方法;透化细胞的方法;从有此需要的患者中清除骨髓中恶性b细胞的方法;试剂盒，用于确定引起哺乳动物细胞膜损伤的多用途试剂的剂量极限;用于确定哺乳动物细胞膜损伤抗体剂量极限的试剂盒;多价细胞膜损伤剂的用途;和细胞膜损伤抗体的应用
5. compound, composition, methods for modulating an immune response, for treating and / or preventing disease, for modulating cell uptake and / or clearance, or a portion thereof, for modulating antigen recognition, processing and / or presentation material derived from cells or portions thereof to diagnose, predict and / or monitor the state of a disease, to distinguish between a necrotic cell or dead cell to enrich dendritic cells, or a subset thereof or precursor thereof , and for detecting a cell, uses of the compound and / or composition, dentitic cells or precursor thereof and a polypeptide, compound and composition, vector polynucleotide, host cell, population, and kit [P] . BRPI1011513A2 . 2016-03-22

机译：化合物，组合物，用于调节免疫应答，用于治疗和/或预防疾病，用于调节细胞摄取和/或清除的调节方法，或其一部分，用于调节源自细胞或其部分的抗原识别，加工和/或呈递材料的化合物，组合物，方法诊断，预测和/或监测疾病状态，区分坏死细胞或死细胞以丰富树突状细胞或其子集或其前体，以及用于检测细胞，化合物和/或组合物的用途，树突状细胞或其前体以及多肽，化合物和组成，载体多核苷酸，宿主细胞，群体和试剂盒