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针对肌腱蛋白的人类抗体和其结合片段

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摘要

本公开涉及针对肌腱蛋白、特别是肌腱蛋白的FBG结构域的完整抗体和结合片段，其可能比亲本抗体具有更低的免疫原性。本公开还涉及包含所述抗体或结合片段的组合物和其中任何一种用于诊断、预后和/或治疗病症如与慢性炎症相关的病症的用途。本公开进一步提供了制备所述抗体的方法。

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公开/公告号CN109152833A

专利类型发明专利
公开/公告日2019-01-04

原文格式PDF
申请/专利权人纳塞恩特公司;
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申请/专利号CN201780019092.X
发明设计人 P·何克塔尔;K·S·米德伍德;E·卡尔伯特;
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申请日2017-02-10
分类号
代理机构北京纪凯知识产权代理有限公司;
代理人张全信
地址英国伦敦
入库时间 2024-02-19 09:22:25

法律信息

法律状态公告日

法律状态信息

法律状态
2019-02-26

实质审查的生效 IPC(主分类):A61K39/395 申请日:20170210

实质审查的生效
2019-01-04

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1. 针对肌腱蛋白的人类抗体和其结合片段 [P] . 中国专利： CN109152833A . 2019-01-04
2. 针对新型冠状病毒核衣壳蛋白的抗体或其抗原结合片段及其应用 [P] . 中国专利： CN112679605A . 2021-04-20
3. pencicillin-binding protein, nucleic acid, antibody or antibody fragment, medicament, pharmaceutical composition, uses of at least one penicillin-binding protein or fragment or variant or fragment thereof, of at least one nucleic acid and of at least one antibody or antibody fragment, in vitro antibody detection methods directed against neisseria meningitidis infection from a penicillin-binding protein, nucleic acid, antibody or an antibody fragment, pharmaceutical composition of at least one penicillin-binding protein or fragment or variant or variant thereof, of at least one nucleic acid and at least one antibody directed against neisseria meningitidis infection from a biological sample of a mammal and in vitro diagnosis of neisseria miningitidis infection from a biological sample from a mammal and monoclonal antibody [P] . BRPI0610802A2 . 2016-11-16

机译：青霉素结合蛋白，核酸，抗体或抗体片段，药物，药物组合物，至少一种青霉素结合蛋白或其片段或变异体或片段，至少一种核酸和至少一种抗体或抗体片段的用途，针对脑膜炎奈瑟菌的青霉素结合蛋白，核酸，抗体或抗体片段感染的体外抗体检测方法，至少一种青霉素结合蛋白或其片段或变异体或变异体，至少一种核酸的药物组合物酸和至少一种针对哺乳动物生物样品中脑膜炎奈瑟氏菌感染的抗体以及来自哺乳动物生物样品中的矿业性奈瑟氏球菌感染的体外诊断和单克隆抗体
4. Preparation of isolated protein, substantially pure or recombinant, isolated trt protein, substantially pure or recombinant isolated trt protein, substantially pure or recombinant, isolated trt protein or a variant thereof, or a fragment, polynucleotide, synthetic, substantially pure or recombinant, isolated nucleic acid, encoding a trt protein, expression vector, transfected cell, non-human animal, or its progeny, transgenic non-human animal, antibody or its binding fragment, antibody, specifically immunoreactive under immunologically reactive conditions, for a trt protein or its immunogenic fragment, processes of determining whether a compound or treatment is a modulator of a trt activity or expression, of determining whether a test compound is a modulator of a trt activity, of preparing recombinant telomerase, to detect a trt gene product in a sample, to detect the presence of d and at least one telomerase positive human cell in a biological sample comprising human cells, to diagnos [P] . BR9711844A . 2000-01-18

机译：分离的蛋白质，基本上纯的或重组的分离的trt蛋白，基本上纯的或重组的分离的trt蛋白，基本上纯的或重组的分离的trt蛋白或其变体或片段，多核苷酸，合成的，基本上纯的或重组的分离的核酸的制备编码trt蛋白的酸，表达载体，转染的细胞，非人类动物或其后代，转基因非人类动物，抗体或其结合片段，抗体，在免疫反应条件下对trt蛋白或其免疫原具有特异性片段，确定化合物或处理是否是trt活性或表达的调节剂，确定测试化合物是否是trt活性的调节剂，制备重组端粒酶以检测样品中trt基因产物的过程，检测包含人细胞的生物样品中d和至少一种端粒酶阳性人细胞的存在，以进行诊断
5. RECOMBINANT PLASMID DNA pFastBac-G2R-IgG, WHICH CONTAINS FRAGMENT OF SMALLPOX VIRUS GENOME, CODING FACTOR OF TUMOUR NECROSIS, BINDING PROTEIN, AND FRAGMENT OF HUMAN GENOME, CODING SECTION OF HEAVY CHAIN OF ANTIBODY G, AND STRAIN OF BACULOVIRUS BvG2RIgG, WHICH PRODUCES SOLUBLE CHIMERIC PROTEIN, WHICH CONSISTS OF SMALLPOX VIRUS PROTEIN, BINDING FACTOR OF TUMOUR NECROSIS, AND FRAGMENT OF HEAVY CHAIN OF HUMAN ANTIBODY G [P] . 俄罗斯专利： RU2376375C2 . 2009-12-20

机译：重组质粒pFastBac-G2R-IgG，其中包含小痘病毒基因组的片段，肿瘤坏死的编码因子，结合蛋白和人类基因的片段，抗体G的重链，猪的糖链和细菌的编码部分嵌合蛋白，由痘痘病毒组成的蛋白，肿瘤坏死的结合因子和人抗体G的重链片段