首页> 中国专利> 一种无毒性的产气荚膜梭菌重组ε毒素和α毒素融合蛋白疫苗及其生产方法

一种无毒性的产气荚膜梭菌重组ε毒素和α毒素融合蛋白疫苗及其生产方法

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摘要

本发明涉及一种无毒性的产气荚膜梭菌重组ε毒素和α毒素融合蛋白疫苗及其生产方法。该疫苗含有的无毒性产气荚膜梭菌ETX突变体和CPA的C末端融合蛋白rETX

著录项

公开/公告号CN109745554A

专利类型发明专利
公开/公告日2019-05-14

原文格式PDF
申请/专利权人中国兽医药品监察所;
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申请/专利号CN201910159102.0
发明设计人刘莹;陈小云;杜吉革;薛麒;朱真;王磊;张莹辉;印春生;李启红;姚文生;康凯;
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申请日2019-03-04
分类号
代理机构北京君智知识产权代理事务所(普通合伙);
代理人郑明
地址 100081 北京市海淀区中关村南大街8号
入库时间 2024-02-19 08:55:43

法律信息

法律状态公告日

法律状态信息

法律状态
2019-06-07

实质审查的生效 IPC(主分类):A61K39/08 申请日:20190304

实质审查的生效
2019-05-14

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1. 一种无毒性的产气荚膜梭菌重组ε毒素和α毒素融合蛋白疫苗及其生产方法 [P] . 中国专利： CN109745554A . 2019-05-14
2. 一种无毒性破伤风毒素和产气荚膜梭菌β毒素重组融合蛋白 [P] . 中国专利： CN109942718A . 2019-06-28
3. Fusion protein Fusion protein The soluble composition of the host cell material Process to generate a neutralizing anti-toxin directed against Clostridium botulinum toxin type A antibody to purify a recombinant fusion protein derived from a Clostridium botulinum toxin type A process to generate an antitoxin neutralizing directed against clostridium difficile toxin type b antibody treatment process process to generate a neutralizing antitoxin directed against clostridium difficile type a toxin composition process to vaccinate an individual to produce neutralizing antitoxin directed against clostridium difficile toxin processing the detection of clostridium antigens difficile in an ample process of purification of toxins from clostridium difficile from a culture and process of generation of a solid dosage form of a bird antitoxin directed against a protein of clostridial toxin [P] . BR9509903A . 1997-11-25

机译：融合蛋白融合蛋白宿主细胞材料的可溶性组成物产生针对A型肉毒梭菌毒素的中和抗毒素的过程纯化源自A型肉毒杆菌毒素的重组融合蛋白的抗体产生针对人肉毒杆菌的抗毒素的过程B型艰难梭菌毒素抗体处理工艺过程，产生针对A艰难梭菌毒素的中和抗毒素组合物，对个体进行疫苗接种，以生产针对艰难梭菌毒素的中和抗毒素，在充足的纯化纯化过程中检测艰难梭菌抗原来源于梭状芽胞杆菌毒素蛋白的鸟抗毒素固体剂型的培养物和固体剂型产生过程中的艰难梭菌毒素
4. Detoxified immunogenic derivative of clostridium perfringens b-toxin or an immunogenic fragment thereof, nucleotide sequence comprising a mutant DNA fragment, clostriduim perfringensm expression system based on a gram-positive bacterium, vaccine to combat clostridium perfrigens infection, process for the preparation of native b-toxin from clostridium perfrigens, and, process for preparing a vaccine to combat infection of clostridium perfrigens. [P] . BR9802361A . 2000-01-11

机译：产气荚膜梭菌b毒素的解毒免疫原性衍生物或其免疫原性片段，包含突变DNA片段的核苷酸序列，基于革兰氏阳性细菌的产气荚膜梭菌表达系统，抗付产气荚膜梭菌感染的疫苗，制备天然b-产高产梭状芽胞杆菌的毒素，以及制备疫苗来抵抗产高产梭状芽胞杆菌感染的方法。
5. "a process for production of tag-free recombinant fusion protein encompassing promiscuous t cell epitope of tetanus toxoid and dog zona pellucida glycoprotein-3 and its use as contraceptive vaccine" [P] . IN2012DE01269A . 2015-10-30

机译： “一种生产无标签重组融合蛋白的方法，该融合蛋白包含破伤风类毒素和狗透明带糖蛋白-3的混杂t细胞表位，并用作避孕疫苗”