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Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo

机译:通过静电组装伤口敷料的组合生长因子疗法改善体内糖尿病性溃疡愈合

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摘要

Chronic skin ulcerations are a common complication of diabetes mellitus, affecting up to one in four diabetic individuals. Despite the prevalence of these wounds, current pharmacologic options for treating them remain limited. Growth factor-based therapies have displayed a mixed ability to drive successful healing, which may be due to nonoptimal delivery strategies. Here, a method for coating commercially available nylon dressings using the layer-by-layer process is described to enable both sustained release and independent control over the release kinetics of vascular endothelial growth factor 165 and platelet-derived growth factor BB. It is shown that the use of strategically spaced diffusion barriers formed spontaneously by disulfide bonds enables independent control over the release rates of incorporated growth factors, and that in vivo these dressings improve several aspects of wound healing in db/db mice.
机译:慢性皮肤溃疡是糖尿病的常见并发症,影响多达四分之一的糖尿病患者。尽管这些伤口盛行,但目前治疗它们的药理选择仍然有限。基于生长因子的疗法已显示出驱动成功治愈的混合能力,这可能是由于非最佳的治疗策略所致。在此,描述了一种使用逐层方法涂覆市售尼龙敷料的方法,该方法能够持续释放并独立控制血管内皮生长因子165和血小板衍生的生长因子BB的释放动力学。结果表明,使用由二硫键自发形成的策略性间隔扩散屏障,可以独立控制掺入的生长因子的释放速率,并且体内这些敷料可改善db / db小鼠伤口愈合的多个方面。

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