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Coronary calcification detected by electron-beam computed tomography and myocardial infarction - The Rotterdam Coronary Calcification Study

机译:电子束计算机断层扫描和心肌梗死检测冠状动脉钙化-鹿特丹冠状动脉钙化研究

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摘要

Aims Available data are insufficient to determine the relation between coronary calcification and coronary events in the general population. We cross-sectionally examined the association between coronary calcification and myocardial infarction in the prospective Rotterdam Coronary Calcification Study. Methods and Results From 1997 onwards, subjects were invited for electron-beam computed tomography scanning to detect coronary calcification. The study was embedded in the population-based Rotterdam Study. Calcifications were quantified in a calcium score according to Agatston's method. Calcium scores were available for 2013 participants with a mean age of 71 years (standard deviation, 5.7 years). A history of myocardial infarction prior to scanning was present in 229 subjects. Compared to subjects in the lowest calcium score category (0-100), the age-adjusted odds ratio for myocardial infarction in subjects in the highest calcium score category (above 2000) was 7.7 (95% confidence interval, 4.1-14.5) for men, and 6.7 (95% confidence interval, 2.4-19.1) for women. Additional adjustment for cardiovascular risk factors only slightly altered the estimates. The association was observed across all age subgroups, i.e. also in subjects of 70 years and older. Conclusion A strong and graded association was found between coronary calcification and myocardial infarction. The association remained at high ages.
机译:目的现有数据不足以确定一般人群中冠状动脉钙化与冠状动脉事件之间的关系。我们在前瞻性鹿特丹冠状动脉钙化研究中横断面检查了冠状动脉钙化与心肌梗塞之间的关系。方法和结果从1997年起,邀请受试者进行电子束计算机断层扫描,以检测冠状动脉钙化。该研究已嵌入基于人口的鹿特丹研究中。钙化根据Agatston方法以钙评分量化。 2013年参与者的平均钙含量为71岁(标准差为5.7岁)。 229位受试者中存在扫描前的心肌梗塞病史。与最低钙得分类别(0-100)的受试者相比,在最高钙得分类别(2000以上)的受试者中,年龄调整后的心肌梗死的优势比为7.7(95%置信区间,4.1-14.5) ,女性为6.7(95%置信区间为2.4-19.1)。心血管风险因素的其他调整仅会使估计值稍有改变。在所有年龄组中均观察到这种关联,即在70岁及以上的受试者中也观察到这种关联。结论发现冠状动脉钙化与心肌梗死之间存在强烈的分级关联。该协会一直保持高龄。

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