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Dosimetric verification of stereotactic body radiation therapy for lung cancer treatment plans using flattening filter-free beams

机译:使用无滤光片展平的立体定向放射疗法对肺癌治疗计划的剂量学验证

摘要

Aims: This study aimed to analyze the dose distribution using different dosimetric tools in conducting pretreatment quality assurance for lung cancer stereotactic body radiation therapy (SBRT) plans with flattening filter free (FFF) beams. Methods: Nine patients with lung cancer treated via SBRT were randomly selected, and their treatment plans were generated using the Eclipse treatment planning system (TPS) with FFF beams. For each patient, the same plan was applied to the Delta4 phantom and MatriXX by the TPS, which calculated the dose distribution. The Delta4 and MatriXX phantoms were then used to measure the actual dose distribution at the linear accelerator, and these measured doses were compared to with the calculated doses. Gamma analysis was employed in verifying the correspondence between the dose distributions. The absolute point doses were measured by a 0.016 mL Microchamber with the RW3 phantom and Thorax phantom. Results: The absolute point doses measured by the 0.016 mL Microchamber were within ±3% of the calculated results for the central point of the RW3 and Thorax phantoms. The Delta4 and MatriXX dose distributions agreed well with the measured and calculated doses, over 98%, based on the 3% maximum dose and 3 mm gamma criteria. Conclusions: Both measured and calculated doses for the Delta4 and MatriXX phantoms agreed well for each patient with lung cancer. The absolute point dose measurements using the 0.016 mL Microchamber exhibited excellent agreement with the TPS calculated between the RW3 and Thorax phantoms.
机译:目的:本研究旨在使用不同的剂量学工具来分析剂量分布,以对具有扁平无滤光片(FFF)光束的肺癌立体定向放射治疗(SBRT)计划进行预处理质量保证。方法:随机选择9例经SBRT治疗的肺癌患者,并使用带有FFF束的Eclipse治疗计划系统(TPS)制定其治疗计划。对于每位患者,TPS将相同的计划应用于Delta4体模和MatriXX,从而计算出剂量分布。然后,将Delta4和MatriXX体模用于测量线性加速器上的实际剂量分布,并将这些测得的剂量与计算出的剂量进行比较。伽马分析用于验证剂量分布之间的对应关系。绝对点剂量通过带有RW3体模和Thorax体模的0.016 mL微室进行测量。结果:0.016 mL微腔室所测量的绝对点剂量在RW3和胸模的中心点的计算结果的±3%之内。基于3%的最大剂量和3 mm的伽玛标准,Delta4和MatriXX的剂量分布与测量和计算的剂量非常吻合,超过98%。结论:Delta4和MatriXX体模的剂量和计算剂量均与每位肺癌患者一致。使用0.016 mL Microchamber进行的绝对点剂量测量与RW3和Thorax体模之间计算的TPS表现出极好的一致性。

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