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Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli

机译:嗅球球菌对二元混合物信息的分析处理

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摘要

Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a mixture cannot be individually identified. This synthetic processing of odor information suggests that individual component representations of the mixture must interact somewhere along the olfactory pathway. The anatomical nature of sensory neuron input into segregated glomeruli with the bulb suggests that initial input of odor information into the bulb is analytic. However, a large network of interneurons within the olfactory bulb could allow for mixture interactions via mechanisms such as lateral inhibition. Currently in mammals, it is unclear if postsynaptic mitral/tufted cell glomerular mixture responses reflect the analytical mixture input, or provide the initial basis for synthetic processing with the olfactory system. To address this, olfactory bulb glomerular binary mixture representations were compared to representations of each component using transgenic mice expressing the calcium indicator G-CaMP2 in olfactory bulb mitral/tufted cells. Overall, dorsal surface mixture representations showed little mixture interaction and often appeared as a simple combination of the component representations. Based on this, it is concluded that dorsal surface glomerular mixture representations remain largely analytical with nearly all component information preserved.
机译:气味很少由单一化合物组成,而是包含大量复杂的化学成分。通常,这些混合物被认为具有独特的品质,与它们的成分组合可能大不相同。在许多情况下,混合物的大部分成分无法单独识别。气味信息的这种合成处理表明,混合物的各个成分表示必须沿着嗅觉途径相互作用。感觉神经元与灯泡一起输入到分离的肾小球中的解剖学性质表明,气味信息最初输入到灯泡中是分析性的。然而,嗅球内大量的中间神经元网络可以通过诸如侧向抑制的机制允许混合物相互作用。目前在哺乳动物中,尚不清楚突触后的二尖瓣/簇状细胞肾小球混合物反应是否反映了分析混合物的输入,或为嗅觉系统进行合成处理提供了初步基础。为了解决这个问题,使用在嗅球二尖瓣/簇状细胞中表达钙指示剂G-CaMP2的转基因小鼠,将嗅球肾小球二元混合物表示形式与每种成分的表示形式进行了比较。总的来说,背表面混合物表示几乎没有混合物交互作用,并且经常以组分表示的简单组合形式出现。基于此,可以得出结论,背表面肾小球混合物的表示在很大程度上保留了几乎所有成分信息的分析能力。

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  • 作者

    Fletcher, Max L.;

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  • 年度 2011
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  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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