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Measuring Blood Pressure in Mice using Volume Pressure Recording, a Tail-cuff Method

机译:使用容积压力记录仪(尾袖法)测量小鼠血压

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摘要

The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system measures the blood pressure in up to 8 mice or rats simultaneously. The CODA tail-cuff system uses Volume Pressure Recording (VPR) to measure the blood pressure by determining the tail blood volume. A specially designed differential pressure transducer and an occlusion tail-cuff measure the total blood volume in the tail without the need to obtain the individual pulse signal. Special attention is afforded to the length of the occlusion cuff in order to derive the most accurate blood pressure readings. VPR can easily obtain readings on dark-skinned rodents, such as C57BL6 mice and is MRI compatible. The CODA system provides you with measurements of six (6) different blood pressure parameters; systolic and diastolic blood pressure, heart rate, mean blood pressure, tail blood flow, and tail blood volume. Measurements can be made on either awake or anesthetized mice or rats. The CODA system includes a controller, laptop computer, software, cuffs, animal holders, infrared warming pads, and an infrared thermometer. There are seven different holder sizes for mice as small as 8 grams to rats as large as 900 grams.
机译:CODA 8通道高通量无创血压系统可同时测量多达8只小鼠或大鼠的血压。 CODA尾套系统使用容积压力记录(VPR)通过确定尾部血量来测量血压。经过特殊设计的压差传感器和闭塞式尾巴袖带可测量尾巴中的总血液量,而无需获取单独的脉冲信号。要特别注意阻塞袖带的长度,以便获得最准确的血压读数。 VPR可以轻松获得深色皮肤啮齿动物(例如C57BL6小鼠)的读数,并且与MRI兼容。 CODA系统可为您测量六(6)个不同的血压参数;收缩压和舒张压,心率,平均血压,尾巴血流量和尾巴血量。可以在清醒或麻醉的小鼠或大鼠上进行测量。 CODA系统包括控制器,便携式计算机,软件,袖套,动物固定器,红外加热垫和红外温度计。小到8克的老鼠到大到900克的老鼠,有七个不同的托座尺寸。

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